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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS13C
All Species:
12.73
Human Site:
Y2247
Identified Species:
35
UniProt:
Q709C8
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q709C8
NP_001018098.1
3753
422390
Y2247
G
I
K
S
I
N
D
Y
N
T
W
F
L
G
V
Chimpanzee
Pan troglodytes
XP_510458
3836
431033
Y2330
G
I
K
S
I
N
D
Y
N
T
W
F
L
G
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_851912
3629
408076
Y2246
G
V
K
P
I
S
D
Y
N
S
W
F
L
G
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BX70
3748
420070
Y2242
A
V
K
S
I
T
D
Y
N
S
W
F
L
G
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511058
3801
426177
C2285
D
I
K
S
V
E
D
C
N
A
W
F
L
G
V
Chicken
Gallus gallus
XP_001233000
3758
422392
C2246
X
V
K
P
I
D
E
C
N
A
W
F
L
G
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001922767
3699
412330
A2223
S
L
M
S
V
A
N
A
N
Y
W
F
L
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001192977
2470
271032
P1109
S
D
N
V
S
L
A
P
P
A
M
T
V
T
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q07878
3144
357831
D1782
S
A
K
D
W
S
T
D
F
E
A
L
A
S
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.9
N.A.
87
N.A.
86.4
N.A.
N.A.
77.2
68.7
N.A.
59.6
N.A.
N.A.
N.A.
N.A.
24.1
Protein Similarity:
100
97.4
N.A.
92
N.A.
93.3
N.A.
N.A.
87.6
82.9
N.A.
76.8
N.A.
N.A.
N.A.
N.A.
41
P-Site Identity:
100
100
N.A.
73.3
N.A.
73.3
N.A.
N.A.
66.6
53.3
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
86.6
N.A.
N.A.
73.3
73.3
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
0
0
0
12
12
12
0
34
12
0
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
23
0
0
0
0
0
0
0
% C
% Asp:
12
12
0
12
0
12
56
12
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
12
12
0
0
12
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
12
0
0
78
0
0
0
% F
% Gly:
34
0
0
0
0
0
0
0
0
0
0
0
0
78
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
34
0
0
56
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
78
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
12
0
0
0
12
0
0
0
0
0
12
78
0
12
% L
% Met:
0
0
12
0
0
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
0
0
12
0
0
23
12
0
78
0
0
0
0
0
0
% N
% Pro:
0
0
0
23
0
0
0
12
12
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
34
0
0
56
12
23
0
0
0
23
0
0
0
12
0
% S
% Thr:
0
0
0
0
0
12
12
0
0
23
0
12
0
12
0
% T
% Val:
0
34
0
12
23
0
0
0
0
0
0
0
12
0
89
% V
% Trp:
0
0
0
0
12
0
0
0
0
0
78
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
45
0
12
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _